Traces of bacterial lipopolysaccharide suppress IFN-gamma-in…
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- DOI 10.4049/jimmunol.151.1.301
- PMID https://pubmed.ncbi.nlm.nih.gov/7686937
- OpenAlex ID W1559126208
- Type Article
- Language EN
- Published 01 Jul 1993
- Volume 151 (1)
- Pages 301–309
- Source The Journal of Immunology
- Publisher American Association of Immunologis…
- FWCI 4.38
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 17 Oct 2026
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Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.
Article 1993 EN
A nitric oxide synthase (iNOS) inducible by cytokines and microbial products contributes to the cytotoxic and antimicrobial activity of mouse macrophages. Bacterial LPS interacts synergistically with IFN-gamma to induce iNOS when both stimuli are added together. In contrast, we show here that pre-exposure of peritoneal macrophages to low concentrations of LPS suppresses the induction of iNOS when…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Christian Bogdan | Cornell University (US) | |
| 2 | Yoram Vodovotz B | Cornell University (US) | |
| 3 | Johanna Paik | Cornell University (US) | — |
| 4 | Q W Xie | Cornell University (US) | — |
| 5 | Carl Nathan | Cornell University (US) |
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